Product Structure:

DOP-DEDA;(2R)-3-(((2-((2-Aminoethyl)amino)ethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dioleate

Size :

1g（Specifications can be customized）

Product details:

DOP-DEDA is a cationic lipid compound commonly used in the formulation of lipid-based nanoparticles for nucleic acid delivery.

In terms of structure, DOP-DEDA consists of a cationic headgroup, which contains a positively charged amine group, and two hydrocarbon chains attached to the headgroup. The hydrocarbon chains provide hydrophobic properties, allowing DOP-DEDA to form lipid bilayers that encapsulate and protect the nucleic acid payload.

DOP-DEDA has a good solubility in organic solvents, such as chloroform and ethanol. This solubility allows for easy incorporation into lipid nanoparticle formulations during the manufacturing process. However, it is important to note that DOP-DEDA may have limited solubility in aqueous solutions, and careful formulation techniques are required to ensure proper dispersion and stability in biological environments.

The stability of DOP-DEDA is crucial for maintaining the integrity and functionality of lipid nanoparticles. It exhibits good stability under physiological conditions, ensuring the long-term viability and efficacy of the nucleic acid-loaded nanoparticles. However, like other lipid-based compounds, DOP-DEDA can be influenced by various factors, such as temperature, pH, and exposure to certain chemicals, which may impact its stability and performance in nucleic acid delivery applications.

Description:

DOP-DEDA, also known as dioleylphosphatidylethanolamine (DOPE), is a type of lipid commonly used in the formulation of lipid nanoparticles (LNPs) for nucleic acid delivery.

DOPE is characterized by its amphiphilic nature, possessing both hydrophilic and hydrophobic regions. This property allows DOPE to interact with both water and lipids, making it an ideal component for the formation of stable lipid bilayers.

DOPE has a high affinity for nucleic acids, particularly mRNA. It can effectively bind and encapsulate mRNA molecules within the lipid nanoparticles, protecting them from degradation and facilitating their delivery to target cells.

The lipid is known for its fusogenic properties, meaning it can facilitate the fusion of LNPs with target cell membranes. This fusion allows for the efficient release of the encapsulated nucleic acids into the cytoplasm of the target cells.

DOPE also contributes to the overall stability of LNPs by providing structural support and enhancing their resistance to environmental factors, such as pH changes and enzymatic degradation.

Furthermore, DOPE has been reported to have a minimal immunogenic response, making it a safe and suitable choice for nucleic acid delivery systems.

Storage conditions:

Store at - 20 ℃. Avoid frequent thawing and freezing.

Note: The products sold by our company are only used for scientific research, not for human experiments or human treatment.

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