Product Structure:

DOTMA;Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium

Size :

1g（Specifications can be customized）

Product details:

Solubility: DOTMA is soluble in a wide range of organic solvents such as chloroform, methanol, and ethanol. However, it is insoluble in water due to its hydrophobic nature.

Stability: DOTMA liposomes are generally stable under proper storage conditions. They can withstand moderate temperature changes, but prolonged exposure to high temperatures or extreme pH conditions may lead to liposome degradation and loss of stability. In addition, DOTMA liposomes may exhibit a tendency to aggregate over time, particularly in the presence of high salt concentrations or divalent cations.

Storage conditions: DOTMA liposomes should be stored at a temperature below the gel-to-liquid crystalline phase transition temperature of the lipid, typically around -20°C or lower. It is important to protect them from light and avoid repeated freeze-thaw cycles, as these can negatively impact the stability and integrity of the liposomes. Additionally, storing DOTMA liposomes in a desiccated form or under inert gas (e.g., nitrogen) can help prevent oxidation and maintain their stability.

Description:

DOTMA (N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride) is a cationic lipid commonly used in gene delivery systems and transfection applications. Here are some key properties of DOTMA: 

1. Cationic nature: DOTMA contains a trimethylammonium headgroup, which gives it a positive charge. This positive charge allows DOTMA to interact with negatively charged molecules, such as nucleic acids, facilitating their delivery into cells. 

2. Lipid bilayer formation: DOTMA is amphiphilic, meaning it has both hydrophobic and hydrophilic regions. The hydrophobic tails of DOTMA can interact with other lipids or fatty acids, forming lipid bilayers or liposomes. This property is important for encapsulating and protecting nucleic acids during delivery. 

3. DNA/RNA complex formation: Due to its positive charge, DOTMA can form complexes with negatively charged nucleic acids, such as DNA or RNA. These complexes, also known as lipoplexes, protect the nucleic acids from degradation and enhance their cellular uptake. 

4. Transfection efficiency: DOTMA has been shown to have high transfection efficiency, meaning it is effective at delivering nucleic acids into cells. This property makes it a valuable tool in gene therapy and molecular biology research.

5. Biocompatibility: DOTMA is generally considered to be biocompatible, meaning it is well tolerated by living organisms. This is an important characteristic for its use in biomedical applications, as it reduces the risk of toxicity or immune response.

Storage conditions:

Store at - 20 ℃. Avoid frequent thawing and freezing.

Note: The products sold by our company are only used for scientific research, not for human experiments or human treatment.

Based on the business model of independent research and development, production and sales integration, the company's products have obvious price advantages compared with similar products on the market. In addition, we also provide professional product customization services.

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